Increased AMP:ATP ratio and AMP-Activated Kinase Activity During Cellular Senescence Linked to Reduced HuR Function
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چکیده
Running title: AMPK-triggered senescence linked to reduced HuR function Abbreviations: ActD, actinomycin D; AICAR, 5-amino-imidazole-4-carboxamide riboside; AMPK, AMP-activated protein kinase; Dex, dexamethasone; ELAV, embryonic lethal abnormal visual; UTR, untranslated region
منابع مشابه
Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function.
Cytoplasmic export of the RNA-binding protein HuR, a process that critically regulates its function, was recently shown to be inhibited by the AMP-activated protein kinase (AMPK). In the present investigation, treatment of human fibroblasts with AMPK activators such as 5-amino-imidazole-4-carboxamide riboside, antimycin A, and sodium azide inhibited cell growth and lowered the expression of pro...
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تاریخ انتشار 2003